What is the Role of Immunohistochemistry in Diagnosing Hematologic Malignancies?
Immunohistochemistry is crucial for diagnosing and classifying hematologic malignancies. This technique uses antibodies to detect specific antigens in cells. For example, CD34 and TdT are markers for lymphoblastic leukemia, while CD20 is a marker for B-cell lymphomas. The expression pattern of these markers helps pathologists determine the lineage and stage of the malignancy, guiding treatment decisions.
