HSPs are implicated in various diseases due to their role in protein homeostasis. For example, in cancer, HSPs are often overexpressed, aiding in the survival of cancer cells by preventing apoptosis and assisting in the folding of oncoproteins. Conversely, in neurodegenerative diseases like Alzheimer's and Parkinson's diseases, malfunction or insufficient levels of HSPs can lead to the accumulation of misfolded proteins, contributing to disease progression.
