HSPs are classified based on their molecular weight into several families, including HSP100, HSP90, HSP70, HSP60, and small HSPs (sHSPs). Each family has distinct functions and mechanisms of action:
HSP100: Involved in protein disaggregation and degradation. HSP90: Assists in stabilizing and folding newly synthesized proteins and is involved in signal transduction. HSP70: Plays a key role in protein folding/unfolding, transport across membranes, and protection against stress. HSP60: Functions primarily in the folding and assembly of mitochondrial proteins. Small HSPs: Prevent aggregation of denatured proteins and assist in refolding.
