The primary role of foam cells in disease is related to their involvement in the development of [atherosclerotic plaques](#). These plaques are the hallmark of atherosclerosis, a significant risk factor for cardiovascular diseases such as heart attacks and strokes. Foam cells contribute to plaque stability and size by secreting pro-inflammatory cytokines and enzymes that can degrade the extracellular matrix. This can lead to plaque rupture and subsequent cardiovascular events.
