What is the Role of Centrocytes in the Immune Response?
The primary role of centrocytes is in the selection process during affinity maturation. After undergoing somatic hypermutation in the dark zone, centrocytes are tested for their affinity to the presented antigen in the light zone. Those with higher affinity BCRs are selected to either become memory B-cells or plasma cells, while those with lower affinity or self-reactive BCRs undergo apoptosis.
