What is the Impact of OxLDL on Cellular Components?
OxLDL has profound effects on various cellular components. It induces endothelial dysfunction by decreasing the availability of nitric oxide (NO), leading to impaired vasodilation. In smooth muscle cells, oxLDL promotes proliferation and migration, contributing to the thickening of the arterial wall. In macrophages, oxLDL uptake leads to foam cell formation and the release of pro-inflammatory cytokines, perpetuating the inflammatory response within the atherosclerotic plaque.
