SLC1A1 plays a crucial role in the glutamate-glutamine cycle. It encodes the EAAT3 transporter, which is responsible for the uptake of glutamate from the synaptic cleft back into neurons. This process is vital for terminating the excitatory signal and preventing neurotoxicity caused by excessive glutamate levels. In addition to its role in neurotransmission, EAAT3 also transports aspartate, another important amino acid.
