In the context of histology, COL3A1 is critical for the structural organization of connective tissues. Type III collagen fibers, encoded by COL3A1, provide tensile strength and elasticity, which are essential for the normal function of organs that undergo stretching and contraction. This includes the vascular system, where type III collagen helps to maintain the integrity of blood vessels, and the skin, where it contributes to elasticity and firmness.
