The enteric nervous system (ENS) is often referred to as the "second brain" due to its extensive network of neurons embedded within the walls of the GI tract. It consists of two primary plexuses: the myenteric plexus and the submucosal plexus. Histologically, these plexuses contain various types of neurons, glial cells, and connective tissue, which coordinate motor functions, glandular secretions, and blood flow within the gut.