Ribonucleic acid (RNA) plays several roles in coding, decoding, regulation, and expression of genes. Unlike DNA, RNA is single-stranded and comes in various forms, including messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA). In histology, RNA can be detected and localized using techniques such as in situ hybridization (ISH). This allows researchers to study gene expression patterns within tissues, providing insights into cellular function and differentiation.