Lesch-Nyhan Syndrome (LNS) is a rare, X-linked recessive disorder caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT). This enzyme is essential for the purine salvage pathway, which recycles purines to synthesize nucleotides. The deficiency leads to an accumulation of uric acid and a range of severe neurological and behavioral abnormalities.
