Insulation in histology refers to the mechanisms and structures that help maintain a stable internal environment in tissues and organs. One of the primary examples of insulation is the myelin sheath, which surrounds the axons of many neurons. This sheath is composed of lipid-rich Schwann cells in the peripheral nervous system and oligodendrocytes in the central nervous system. The main function of this insulation is to increase the speed of electrical signal transmission along the nerve fibers.