HSIL, or High-Grade Squamous Intraepithelial Lesion, represents a spectrum of abnormal cellular changes in the squamous cells lining the cervix. These changes are graded as "high-grade" due to their potential to progress to invasive cervical cancer if left untreated. HSIL often reflects more severe dysplasia compared to Low-Grade Squamous Intraepithelial Lesion (LSIL).