Grading in histology refers to the classification of a tumor based on the appearance of its cells under a microscope. This process evaluates how much the tumor cells differ from normal cells in terms of size, shape, and organization. The goal is to predict the aggressiveness or malignancy of the tumor. Grading systems vary depending on the type of cancer but commonly used systems include the Gleason score for prostate cancer and the Bloom-Richardson grading system for breast cancer.