COX-2, or Cyclooxygenase-2, is an enzyme that plays a significant role in the inflammatory response. It is one of the two isoforms of cyclooxygenase, the other being COX-1. COX-2 is an inducible enzyme, meaning it is produced in response to inflammatory stimuli, such as cytokines and growth factors, unlike COX-1 which is constitutively expressed in most tissues.