Clark level refers to the anatomical level of invasion of melanoma in the skin. It ranges from Level I to Level V, each representing a deeper level of skin penetration.
- Level I: Melanoma confined to the epidermis (also known as in situ melanoma). - Level II: Invasion into the papillary dermis. - Level III: Filling the papillary dermis and extending to the interface with the reticular dermis. - Level IV: Invasion into the reticular dermis. - Level V: Invasion into the subcutaneous tissue.
