The process of pathological staging involves several steps, beginning with the biopsy or surgical removal of the tissue. The tissue is then fixed, sectioned, stained, and examined microscopically by a pathologist. The pathologist looks for specific features such as the degree of differentiation, mitotic rate, and presence of necrosis. The information gathered is used to assign a stage to the disease, typically following a standardized system such as the TNM staging system.
