Aggrecan is a large, complex proteoglycan that plays a crucial role in the structure and function of cartilaginous tissues. It is one of the major components of the extracellular matrix (ECM) in cartilage, contributing to its resilience and ability to withstand compressive forces. The core protein of aggrecan is heavily glycosylated, with numerous glycosaminoglycan (GAG) chains attached, primarily chondroitin sulfate and keratan sulfate.
