What Histological Features Distinguish Neoplastic Cells?

Several histological features can help distinguish neoplastic cells from normal cells:

1. Cellular and Nuclear Pleomorphism: Neoplastic cells often exhibit variability in size and shape, both in their cytoplasm and nuclei.
2. Hyperchromasia: Neoplastic cells frequently have darker-staining nuclei due to increased DNA content.
3. High Mitotic Activity: An increased number of mitotic figures is often observed in neoplastic tissues.
4. Loss of Orientation: Neoplastic cells may lose their normal orientation and organization within the tissue.
5. Increased Nuclear-Cytoplasmic Ratio: Neoplastic cells typically have a larger nucleus relative to their cytoplasm.