The histological changes post-ligation can be categorized into immediate and long-term effects:
1. Immediate Changes: These include the formation of a blood clot at the ligation site, endothelial cell damage, and the initiation of an inflammatory response. 2. Long-term Changes: Over time, you may observe neovascularization, fibrosis, and sometimes calcification at the site of ligation. Additionally, the surrounding tissues may show signs of hypoxia and subsequent cellular adaptations.
