Upon successful treatment with BiTEs, histological analysis often reveals several key changes:
1. Infiltration of T cells: The presence of increased T cells within the tumor microenvironment. 2. Tumor Cell Apoptosis: Signs of apoptosis in cancer cells, such as nuclear fragmentation and cytoplasmic shrinkage. 3. Reduction in Tumor Size: Observable decreases in the size and density of the tumor mass.
