Disruption of the RB pathway can lead to uncontrolled cell proliferation, a hallmark of cancer. Mutations in the RB1 gene, which encodes the RB protein, are commonly observed in various cancers such as retinoblastoma, osteosarcoma, and small cell lung carcinoma. Additionally, hyperactivation of CDKs or loss of CDK inhibitors can also impair RB function, further contributing to oncogenesis.
