What Happens When the RAS-MAPK Pathway is Dysregulated?
Dysregulation of the RAS-MAPK pathway is implicated in various diseases, particularly cancer. Mutations in RAS, RAF, or other components can lead to uncontrolled cell proliferation and survival, contributing to oncogenesis. For instance, mutations in the KRAS gene are commonly found in cancers such as pancreatic, colorectal, and lung cancer.
