Using an incorrect fixative can result in several issues: - Poor Morphological Preservation: The tissue may shrink, swell, or become distorted. - Loss of Antigenicity: Some fixatives can mask or destroy antigens, making it difficult to perform immunohistochemistry. - Degradation of Ultrastructure: Fine cellular details observed under an electron microscope may be lost. - Altered Chemical Composition: The fixation process might alter or remove biochemical constituents of the tissue.
