In GSD Type I (Von Gierke Disease), histology reveals extensive glycogen accumulation within the hepatocytes, often causing cellular swelling and distortion of the hepatic architecture. GSD Type II (Pompe Disease) shows glycogen accumulation within lysosomes, leading to vacuolation of muscle fibers. GSD Type III (Cori/Forbes Disease) displays similar features to Type I but also includes abnormal glycogen with shorter outer chains.
