Certain muscular disorders can affect the structure and function of the I band. For example, Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD) involve mutations in the dystrophin gene, leading to instability of the muscle fiber membrane and affecting the overall sarcomere structure, including the I band. Additionally, conditions that impact actin and its associated proteins can directly affect the I band's integrity and function.
