Several factors can lead to the degradation or loss of elastic fibers:
1. Aging: As we age, the production of elastin decreases, and existing fibers become fragmented. 2. Ultraviolet (UV) Radiation: Chronic exposure to UV light can degrade elastin through the generation of free radicals. 3. Inflammation: Chronic inflammatory conditions can lead to the enzymatic degradation of elastic fibers by enzymes like elastase. 4. Genetic Disorders: Conditions such as Marfan Syndrome and Cutis Laxa are characterized by defects in the structure or production of elastic fibers.
