Several factors can contribute to protein misfolding, including: 1. Genetic Mutations: Alterations in the DNA sequence can lead to the production of aberrant proteins that are prone to misfolding. 2. Environmental Stressors: Conditions such as high temperature, oxidative stress, and pH changes can disrupt the delicate balance of protein folding. 3. Errors in Post-Translational Modifications: Incorrectly added chemical groups can lead to improper folding.
