Thrombolytics, also known as fibrinolytic agents, are drugs used to dissolve blood clots by breaking down fibrin, the protein that helps hold clots together. These agents are crucial in treating conditions like myocardial infarction, stroke, and deep vein thrombosis, where blood clots obstruct normal blood flow. The clinical application of thrombolytics is intertwined with histological studies as they directly impact the cellular and tissue architecture of the vascular system.