How do Thrombolytics Work at the Histological Level?
At the histological level, thrombolytics target the fibrin matrix of a clot. They convert plasminogen, a precursor protein found within the clot, into plasmin, an active enzyme that digests fibrin. This process changes the structural integrity of the clot, leading to its dissolution. Histological examination reveals that thrombolytics affect the endothelial cells lining blood vessels, which are crucial for maintaining vascular health and preventing thrombosis.
