What are the Tissue-Specific Manifestations of Metabolic Disturbances?
Different tissues exhibit unique responses to metabolic disturbances:
Liver: The liver is a primary site for metabolic processing. Conditions such as non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) show lipid deposits, inflammation, and fibrosis. Muscle: Skeletal muscle can exhibit atrophy or hypertrophy depending on the nature of the metabolic disturbance, such as in cachexia or anabolic steroid use. Adipose Tissue: In obesity, adipose tissue undergoes hypertrophy and hyperplasia, and may show increased inflammation. Pancreas: Islet cell hyperplasia or atrophy can be observed in diabetes mellitus, reflecting the pancreas's attempt to regulate glucose levels.
