What are the Structural Features of Calcium Binding Motifs?
The structural features of calcium binding motifs are essential for their function. For instance:
- EF-hand Motif: This motif consists of a 12-residue loop flanked by two alpha helices. The loop contains specific amino acids that coordinate the binding of the Ca2+ ion.
- C2 Domain: The C2 domain typically consists of eight beta strands forming a beta-sandwich structure. Calcium ions are coordinated by loops connecting the beta strands.
- Annexin Repeats: These repeats form a characteristic alpha-helical structure that binds calcium ions and phospholipids, facilitating membrane interactions.
