The process of cornification can be divided into several stages:
Keratinocyte Differentiation: In the stratum basale, keratinocytes begin to produce keratin and migrate upwards. Formation of the Stratum Granulosum: Here, keratinocytes produce keratohyalin granules and lamellar bodies, which are crucial for the later stages of cornification. Stratum Corneum Formation: The final stage where keratinocytes become corneocytes, losing their nuclei and organelles, and forming a dense, waterproof layer rich in keratin.
