What are the Risk Factors for Malignant Transformation?
Several factors increase the risk of malignant transformation:
Genetic Predisposition: Inherited mutations in genes like BRCA1 and BRCA2 increase the risk. Environmental Exposures: Factors such as smoking, radiation, and exposure to carcinogens. Chronic Inflammation: Conditions like chronic hepatitis or inflammatory bowel disease can predispose to cancer. Infections: Certain viruses like HPV and EBV are known to contribute to cancer development.
