What are the Regulatory Mechanisms of the Ryanodine Receptor?
Several mechanisms regulate the activity of the RyR. These include direct binding of calcium, modulation by associated proteins such as calmodulin, phosphorylation by kinases like PKA, and interaction with other molecules such as ATP. Additionally, the receptor can be modulated by reactive oxygen species (ROS) and nitric oxide (NO), which can alter its sensitivity and function.
