What are the Pathological Implications of Cx43 Dysfunction?
Mutations or altered expression of Cx43 are associated with several diseases. In the heart, aberrant Cx43 expression can lead to arrhythmias and cardiomyopathies. In the brain, Cx43 dysfunction is implicated in neurological disorders such as epilepsy and stroke. Additionally, altered Cx43 expression is found in cancers, affecting cell proliferation and tumor progression.
