What are the Limitations of Chromogranin as a Marker?
While chromogranin is a valuable marker for neuroendocrine cells, it is not entirely specific. Other cell types, particularly certain immune cells, can also express chromogranin. Additionally, not all neuroendocrine tumors produce high levels of chromogranin. Therefore, chromogranin staining is often used in conjunction with other markers, such as synaptophysin and neuron-specific enolase, to increase diagnostic accuracy.
