The prognosis of MDS-EB is influenced by several factors, including the percentage of blasts in the bone marrow and peripheral blood, cytogenetic abnormalities, and the degree of cytopenias. Histological evaluation plays a crucial role in determining the blast count and the extent of dysplasia. Cytogenetic analysis can reveal chromosomal abnormalities such as deletions, translocations, and aneuploidies, which are critical for risk stratification.