From a histological perspective, the presence and concentration of NMN can significantly impact tissue health. For instance, adequate levels of NAD+ are necessary for the function of sirtuins—a family of proteins involved in cellular stress resistance and longevity. In tissues, NAD+ is vital for maintaining the integrity of mitochondria, the cellular powerhouses. Mitochondrial dysfunction is often linked to histological changes such as cell atrophy and apoptosis.
