What are the Histological Features of Premature Aging?

Premature aging is marked by several distinct histological features. These include:

Cellular Senescence: An increased number of senescent cells, which cease to divide and exhibit altered function.
Telomere Shortening: Reduced telomere length in cells, leading to genomic instability and cellular dysfunction.
DNA Damage: Accumulation of DNA damage and impaired repair mechanisms.
Mitochondrial Dysfunction: Alterations in mitochondrial structure and function, impacting cellular energy production.
Extracellular Matrix (ECM) Changes: Degradation and disorganization of the ECM, affecting tissue integrity.