What are the Histological Features of Premature Aging?
Premature aging is marked by several distinct histological features. These include:
Cellular Senescence: An increased number of senescent cells, which cease to divide and exhibit altered function. Telomere Shortening: Reduced telomere length in cells, leading to genomic instability and cellular dysfunction. DNA Damage: Accumulation of DNA damage and impaired repair mechanisms. Mitochondrial Dysfunction: Alterations in mitochondrial structure and function, impacting cellular energy production. Extracellular Matrix (ECM) Changes: Degradation and disorganization of the ECM, affecting tissue integrity.
