PAHs are known to cause a variety of histological changes in tissues. These changes can include:
1. Cellular damage: PAHs can induce oxidative stress, leading to cellular damage and apoptosis. 2. DNA adduct formation: Reactive intermediates of PAHs can bind to DNA, forming DNA adducts, which can lead to mutations and cancer. 3. Inflammation: PAHs can trigger inflammatory responses, particularly in lung and skin tissues. 4. Histopathological changes: Chronic exposure to PAHs can result in histopathological alterations such as hyperplasia, metaplasia, and even neoplasia.
