What are the Histological Changes Due to Neurotransmitter Imbalance?
Histologically, neurotransmitter imbalances can lead to visible changes in neural tissue. For instance, in Parkinson's disease, there is degeneration of dopamine-producing neurons in the substantia nigra. This can be observed through a reduction in the pigmentation of the substantia nigra in brain sections. In cases of chronic stress, one might observe changes in the density of dendritic spines, which affects synaptic connectivity.
