Nucleolin is involved in several crucial cellular functions:
Ribosome Biogenesis: Nucleolin is essential for the transcription of rRNA genes, processing of pre-rRNA, and assembly of ribosomal subunits. Chromatin Remodeling: It assists in the organization of chromatin structure, facilitating gene transcription and replication. Cell Cycle Regulation: Nucleolin plays a role in cell proliferation by regulating the cell cycle at multiple stages. Signal Transduction: It participates in various signaling pathways, impacting cell growth and stress responses. RNA Stabilization: Nucleolin binds to specific RNA sequences, stabilizing them and influencing their translation.
