Decorin has multiple functions in the ECM, including:
Collagen Fibrillogenesis: Decorin regulates collagen fiber formation by binding to collagen fibrils, thereby ensuring proper fibril spacing and diameter. Tissue Repair: Decorin is involved in wound healing by modulating the activity of growth factors and cytokines. Cell Signaling: Decorin interacts with various cell surface receptors, such as the epidermal growth factor receptor (EGFR) and insulin-like growth factor-I receptor (IGF-IR), influencing cellular processes like proliferation, migration, and differentiation. Anti-tumor Activity: Decorin has been shown to inhibit tumor growth and metastasis by antagonizing growth factor receptors and inducing apoptosis in cancer cells.
