Abnormal levels of FGF23 can lead to various health issues:
Hypophosphatemia: Elevated levels of FGF23 can cause low serum phosphate, leading to bone disorders such as osteomalacia and rickets. Hyperphosphatemia: Low levels of FGF23 can result in high serum phosphate, increasing the risk of cardiovascular disease and vascular calcification. Chronic Kidney Disease (CKD): Elevated FGF23 is often observed in CKD, contributing to complications like left ventricular hypertrophy and increased mortality.
