Although the criteria may vary depending on the specific grading system, some common factors include:
Cell Differentiation: The extent to which cancer cells resemble normal cells. Poorly differentiated cells tend to be more aggressive. Mitotic Activity: The number of cells undergoing division. A higher mitotic rate indicates rapid tumor growth. Architectural Patterns: The organization of cells and structures within the tissue. Abnormal patterns can suggest higher grades. Nuclear Features: The size, shape, and appearance of cell nuclei. Nuclear pleomorphism and hyperchromasia are markers of higher grades.
