What are the Common Techniques Used in Histology to Study Drug Combinations?
Several histological techniques are employed to study the effects of drug combinations on tissues:
- Hematoxylin and Eosin (H&E) Staining: This is the most common staining technique, providing a general overview of tissue architecture and cellular details. - Immunohistochemistry (IHC): This technique uses antibodies to detect specific proteins, allowing for the identification of biomarkers affected by drug combinations. - In Situ Hybridization (ISH): This method detects specific nucleic acid sequences within tissue sections, useful for studying gene expression changes. - Electron Microscopy: Offers high-resolution images of cellular ultrastructure, helping to visualize drug-induced subcellular changes.
