Histological examination of renal parenchymal disease often reveals several key changes:
Glomerulosclerosis: Hardening and scarring of the glomeruli due to increased extracellular matrix deposition. Tubulointerstitial Fibrosis: Accumulation of fibrous tissue in the tubules and interstitium, leading to impaired renal function. Inflammatory Infiltrates: Presence of immune cells such as lymphocytes and macrophages within the renal parenchyma. Vascular Changes: Thickening and narrowing of the renal blood vessels, which can reduce blood flow and worsen kidney function.
