What are the Clinical Implications of Type III Collagen Deficiency?

Deficiencies or mutations in type III collagen can lead to several clinical conditions. One well-known disorder is Ehlers-Danlos Syndrome (EDS), specifically the vascular type (type IV). Patients with this condition have fragile blood vessels, skin, and internal organs due to defective type III collagen. Another condition associated with type III collagen mutations is aneurysms, particularly in the aorta, due to weakened vessel walls.