What are the Clinical Implications of Squamous Metaplasia?
While squamous metaplasia itself is benign and reversible, it can be a precursor to more serious conditions. Persistent metaplasia can lead to dysplastic changes, which may progress to carcinoma. For instance, in the cervical transformation zone, persistent HPV infection in the presence of squamous metaplasia can lead to cervical cancer. Therefore, monitoring and managing the underlying causes is crucial for preventing progression to malignancy.
